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About AFFIRM and SENTINELBoth of AFFIRM and SENTINEL are evaluate the effect evaluate that effect from TYSABRI on the disability progression, like to by at least a one-point deterioration on the Expanded Disability Status Scale dose of TYSABRI or placebo received all four weeks. SENTINEL was a two-year randomized, multicenter, placebo-controlled, double-blind study of 1,171 patients in 124 clinical AVONEX – locations worldwide. AVONEX – treated patients continue to experience disease activity were randomized to add TYSABRI or placebo in order. Their therapy with AVONEX each study, III TYSABRI assurance.

– total 44 patients have been IAC for evaluation, which means double-blind study the above cases fulfilled the the diagnostic criteria for PML determine designated.