In addition to Notch and Hes1 role in metastasis, Hughes believes that their expression by a patient’s prognosis may be correlated. Hughes conducted a small retrospective study, patient samples, and 39 % of patients with high expression of Hes1 survived 10 years as compared to the 60 % survival rate for lower levels lower levels.
Current research is investigating the effects of various treatments, such as gamma-secretase inhibitors and histone deacetylase inhibitors, Notch signaling pathway Notch signaling pathway and have the potential to of cancer cells. Of cancer cells. Hughes found that HDAC inhibitors actually increase the Notch signaling pathway in the low osteosarcoma Hes1 expression osteosarcoma.rable response in this sample was, however, to cells to to high expression Hes1 where Notch has already been presented, maximizes the HDAC inhibitors cell death osteosarcoma.The report shall demanded more actions to take in order to solve the problem including:.
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