Anticonvulsant drug valproate poses greater birth-defect risk than suspected Use of the anticonvulsant drug valproate during pregnancy might pose a significantly great risk of birth defects than does usage of other antiseizure medicines. In the March 22 problem of Neurology, researchers from the UNITED STATES AED Pregnancy Registry at Massachusetts General Hospital report that ladies taking valproate by itself had a fourfold increased risk of having a child with a major malformation, compared with the risk among women taking other anticonvulsants. The essential message for ladies who take valproate is usually to program ahead if they want to have kids online pharmacy .