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The medication was marketed as a cardiovascular disease medication, but afterwards discovered to cause serious side effects, including blindness from a unique form of cataracts. It had been pulled from the market and abandoned. We’ve learned a whole lot in 50 years, said Glass. Maybe there’s a means now to create a new drug that mimics the cholesterol inhibition without the side effects. .. Cholesterol precursor suppresses inflammatory response genes, causes atherosclerosis Atherosclerosis – the hardening of arteries that is a primary trigger of coronary disease and death – has long been presumed to be the fateful consequence of complicated interactions between overabundant cholesterol and resulting inflammation in the heart and arteries.