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Previous pre-clinical analysis and human imaging research led by Boston Kids's Medical center neurologist Mustafa Sahin, MD, PhD, provides identified defects in axons and their orientation into nerve tracts in TSC, in TSC sufferers that develop autism particularly, supporting the growing proven fact that autism outcomes from a miswiring of connections in the developing mind. Sahin's lab in addition has shown that the defects occur from a biological pathway which can be reversed using the medication rapamycin.