The primary efficacy measure may be the Neuropsychiatric Inventory or NPI. Secondary outcome measures consist of assessments of disease intensity, behavioral abnormalities, cognition, actions of daily living, standard of living and caregiver strain. Regular safety assessments will be conducted. Jeffrey Cummings, MD can be a paid consultant of Avanir Pharmaceuticals, Inc. Furthermore, Dr. Cummings may be the inventor of the Neuropsychiatric Inventory and receives royalties because of its use.. Avanir initiates enrollment in AVP-923 Stage II clinical trial for treatment of agitation in Advertisement patients Avanir Pharmaceuticals, Inc. today announced the enrollment of the 1st patient in research AVR-131.Scientists today possess little understanding of how or what happens when Ras proteins type small, nano-sized clusters on the membrane. The researchers hope that a better understanding of how Ras proteins cluster collectively and connect to various other proteins in cells provides them one step closer to developing therapeutic targets for Ras-driven tumors. ‘It is these nanoclusters, these transient substructures on the cell membrane that disassemble and assemble quickly, that are involved in signal transmission,’ Gorfe said. Gorfe's computer simulations showed Ras proteins cluster together, or type aggregates, on the cell membrane. Which led him to question what they could do there. ‘Would the proteins simply sit passively rather than have an effect on the membrane at all? Or would they somehow change its form? That is the query we asked,’ Gorfe said.