R&D expenditure in the fourth quarter of 2011 increased by $3.1 million compared to 2010 due primarily to higher clinical trials costs in 2011. General and administrative expense in the fourth one fourth of 2011 decreased by $0.2 million from $2.6 million in 2010 thanks to lower professional service-related costs in 2011 primarily. The reduction in cash, money equivalents and marketable securities of $9.5 million from September 30, 2011 primarily reflects our fourth quarter operations-related cash burn off of approximately $9.4 million. The web lack of $44.8 million for 2011 symbolizes an increased lack of $42.3 million, when compared to the net loss of $2.5 million for the same period in 2010 2010, and is primarily due to the two one-time items discussed in the last paragraph.The hippocampus could be vulnerable to BACE1 blockers particularly, he noted, because its inhabitants of neurons is continually being reborn, which may play a role in forming new memories. The neurons have to grow brand-new axons that in turn must connect them with brand-new targets. Axonal guidance is a continuous need. It isn’t all bad information, Vassar mentioned. These BACE1 blockers may be useful at a particular dose that will reduce the amyloid plaques however, not high plenty of to interfere with the wiring. Understanding the normal function of BACE1 will help us avoid potential medication side effects.