At a median follow-up of 12 months , one individual provides progressed. The most common grade 3 or 4 4 adverse events experienced by sufferers in the study were neutropaenia , rash , and myalgia . The rash was generally found to be self-small and did not occur on re-exposure to the drug usually. Three patients were taken off treatment due to a detrimental event linked to one or both of the study drugs but were eligible for toxicity assessment and included 1 with rash and 1 with arterial thrombosis, both of which occurred during cycle 1.Study author Felix Engel, an instructor in pediatrics at the hospital, says he is interested in the molecular mechanisms of how the drugs work, and happens to be searching for better drugs to be able to develop therapies that would be appropriate for humans. The study nevertheless demonstrates that it’s possible to rescue heart muscle, which does not occur naturally after a heart attack. Following a coronary attack the damaged heart muscle is changed by scar tissue, which can impair the heart’s pumping capacity and lead to life-threatening abnormal center rhythms.