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However, this is a distressing procedure for the individual in fact it is often only performed to verify diagnosis in situations of chronic kidney disease. Most of the other markers I described involve either a blood or urine sample just, so they are used on a more program basis. What do you consider would be the main difficulties in increasing our knowledge of Alport syndrome? I believe we have an excellent sense of the disease when it comes to its inheritance design and exactly what happens to individuals who develop the disease. When it comes to therapeutic intervention, we have to set up the endpoints that could be found in a clinical study to assess the ramifications of the intervention on confirmed measure.